DYNAMICS OF HIV-CONTAINING COMPARTMENTS IN MACROPHAGES REVEAL SEQUESTRATION OF VIRIONS AND TRANSIENT SURFACE CONNECTIONS.

Dynamics of HIV-containing compartments in macrophages reveal sequestration of virions and transient surface connections.

During HIV pathogenesis, infected macrophages behave as "viral reservoirs" that accumulate and retain virions within dedicated internal Virus-Containing Compartments (VCCs).The nature of VCCs remains ill characterized and controversial.Using wild-type HIV-1 and a replication-competent HIV-1 carrying GFP internal to the Gag precursor, we analyzed th

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Assessing the Strength Characteristics and Environmental Impact of Fly-Ash Geopolymer Mortar for Sustainable Green Patch Repair: A Pathway towards SDGs Achievement

The primary factor influencing the service life of building structures is concrete deterioration caused by steel bar corrosion, which holds significant impact.Implementing maintenance techniques is crucial for mitigating both environmental and economic ramifications, thereby aligning with the Sustainable Development Goals (SDGs) agenda.Patch repair

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Pleiotropy constrains the evolution of protein but not regulatory sequences in a transcription regulatory network influencing complex social behaviours

It is increasingly apparent that genes and networks that influence complex behaviour are evolutionary conserved, which is paradoxical considering that behaviour is labile over evolutionary timescales.How does adaptive change in behaviour arise if behaviour is controlled by conserved, pleiotropic, and likely evolutionary constrained genes? Pleiotrop

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